Researchers get closer to pill to stop Type 2 Diabetes
Mar 29, 2017 19:06:39 GMT -5
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Post by Kevin Hamilton on Mar 29, 2017 19:06:39 GMT -5
mentalfloss.com/article/93771/researchers-make-progress-pill-stop-type-2-diabetes
Pharmaceutical researchers are one step closer to making a pill that can reverse the symptoms of type 2 diabetes. They published their research in the journal Nature Chemical Biology.
The authors of the new study wondered if they could address the problem farther up in the pipeline by convincing the body to respond to insulin again. They created a compound that blocks the release of a chemical called low molecular weight protein tyrosine phosphatase (LMPTP), an enzyme that’s previously been implicated in insulin resistance.
They gave the drugs to a group of obese, diabetic mice by mouth, once a day for four weeks, all the time monitoring the rodents’ blood sugar and insulin resistance. In that short time, the animals’ bodies began responding to insulin and their blood sugar began to stabilize. The mice experienced no side effects. The next step will be testing the drug in other animals, and then in people. Lead researcher Stephanie Stanford of the University of California, San Diego, is hopeful the pill’s success will translate into the human body and reduce the need for insulin injections and other drugs.
The authors of the new study wondered if they could address the problem farther up in the pipeline by convincing the body to respond to insulin again. They created a compound that blocks the release of a chemical called low molecular weight protein tyrosine phosphatase (LMPTP), an enzyme that’s previously been implicated in insulin resistance.
They gave the drugs to a group of obese, diabetic mice by mouth, once a day for four weeks, all the time monitoring the rodents’ blood sugar and insulin resistance. In that short time, the animals’ bodies began responding to insulin and their blood sugar began to stabilize. The mice experienced no side effects. The next step will be testing the drug in other animals, and then in people. Lead researcher Stephanie Stanford of the University of California, San Diego, is hopeful the pill’s success will translate into the human body and reduce the need for insulin injections and other drugs.
